PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION Russian patent published in 2016 - IPC A61K31/439 A61K31/18 A61K47/10 A61K47/26 A61K47/32 A61K47/38 A61P13/02 A61P13/08 

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics. Described is double-layered tablet for oral administration, containing thin layer with prolonged release and thin layer with immediate release. Prolonged release layer consists of Tamsulosin or its pharmaceutically acceptable salt, polymer, which forms Hydrogel, and polyethylene glycol with molecular weight of 8000. Layer with immediate release includes solifenacin or its pharmaceutically acceptable salt and hydrophilic substance. Hydrophilic substance is selected from group consisting of D-mannitol, maltose, polyethylene glycol and polivilpirrolidone. Said hydrophilic substance is used as binding substance and its content ranges from 5 to 10 wt% of weight of immediate release part.

EFFECT: invention provides producing pharmaceutical composition in form of single preparative form (combined preparative form), having bioavailability, which is equivalent to bioavailability of known formulations with one drug.

14 cl, 3 dwg, 3 ex, 2 tbl