CHROMON OXIME NEW DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS Russian patent published in 2018 - IPC C07D495/04 A61K31/407 A61P25/16 

Abstract RU 2672569 C2

FIELD: chemical-pharmaceutical industry.

SUBSTANCE: invention relates to a novel chromon oxime derivative of formula (I), also relates to pharmaceutical compositions containing said compound, and to their use in the treatment or prevention of conditions associated with altered glutamatergic signaling and/or function, or conditions that can be influenced, changing the level of glutamate or signal transmission, in particular Parkinson's disease.

.

EFFECT: technical result: new compound of formula (I) is obtained which is a modulator of brain permeability mGluRs of the nervous system and, in addition, provides an advantageous high permeability of the brain after oral administration.

14 cl, 10 dwg, 3 ex, 3 tbl

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RU 2 672 569 C2

Authors

Charvin, Delphine

Manteau, Baptiste

Pomel, Vincent

Conquet, Francois

Dates

2018-11-16Published

2015-08-27Filed