METHOD OF BIODEGRADATION OF DROTAVERINE HYDROCHLORIDE Russian patent published in 2013 - IPC C12N1/20 C12R1/01 

FIELD: biotechnologies.

SUBSTANCE: method is proposed for biodegradation of drotaverine hydrochloride (spasmolytic NOSHPA). The method provides for the process of reaction of drotaverine hydrochloride with cells of the strain Rhodococcus rhodochrous, Institute of Ecology and Genetics of Microorganisms 608. The process is performed under aerobic conditions in the medium containing sources of carbon, nitrogen, phosphorus, mineral salts. At the same time the additional source of carbon in the nutrient medium may be glucose. The cells of the strain Rhodococcus rhodochrous, Institute of Ecology and Genetics of Microorganisms, 608, may be used in the immobilised form. The strain is stored in the Regional Profiled Collection of Alkanotroph Microorganisms (acronym of the collection of the Institute of Ecology and Genetics of Microorganisms). Duration of biodegradation of drotaverine hydrochloride makes at least 80% for 25 days.

EFFECT: invention makes it possible to reduce time of biodestruction of drotaverine hydrochloride and to consider the used strain as a potential agent for cleaning of environment.

4 cl, 4 dwg, 3 ex