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(19)

(11)

2 498 984

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P35/00(2006-01-01)

A61P29/00(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2010108507/04, 2008-09-12

(24)

Start date

2008-09-12

(22)

Actual filing date

2008-09-12

(45)

Published

2013-11-20

(72)

Inventor

Mezhe LoranBettajeb KarimaGalon EhrveDemanzh LjukUmata Nassima

(73)

Holder

Sentr Nas'Onal' De La Reshersh S'EntifikJuniversit De RenneJuniversit Paris Deskarte

PERHARIDINES AS CDK INIHIBITORS Russian patent published in 2013 - IPC C07D471/04 A61K31/437 A61P35/00 A61P29/00 A61P25/00

Abstract RU 2498984 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel imidazo[4,5-b]pyridine derivatives of formula I as well as salts, hydrates and stereoisomers thereof, where B-R₂ and R₄-A-R₃ are selected from groups indicated in claim 1, R₁ denotes a C₁-C₆ alkyl group, optionally branched, R₅ denotes a hydrogen atom. The invention also relates to a compound of formula II 3-substituted 7-chloro-5-iodo-imidazo[4,5b]pyridine, a method of producing imidazo[4,5-b]pyridine derivatives of formula I, a pharmaceutical composition based on the compound of formula I and use thereof.

EFFECT: obtaining novel derivatives having CDK inhibiting properties.

10 cl, 17 dwg, 6 tbl, 6 ex

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RU 2 498 984 C2

Authors

Mezhe Loran

Bettajeb Karima

Galon Ehrve

Demanzh Ljuk

Umata Nassima

Dates

2013-11-20—Published

2008-09-12—Filed