FIELD: chemistry.
SUBSTANCE: present invention relates to a new pyrazole[1.5-a]pyrimidine derivative of formula [1]: 
, where ring A is a substituted pyrazole ring condensed with a neighbouring pyrimidine ring having formula 
, and group E is one of the following groups (ii)-(v): 
, and the rest of the radicals are defined in the description. The invention also relates to pharmaceutical compositions containing such compounds.
EFFECT: disclosed compositions and compositions have antagonistic effect on CB1 cannabinoid receptor.
19 cl, 82 tbl, 500 ex
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