FIELD: medicine.
SUBSTANCE: this invention relates to immunology. Isolated peptide-epitope derived from the kinetochore-associated molecule 2 (KNTC2) is proposed and able to induce cytotoxic T-lymphocytes (CTL) in the presence of an antigen-presenting cell (APC) bearing HLA-A*0201. A polynucleotide encoding it, a vector, a host cell for producing said peptide is also described. In addition, methods for inducing APC and CTL, a composition for inducing CTL isolated by APC in combination with a peptide, a pharmaceutical composition for the treatment and/or prevention of a malignant tumor expressing KNTC2 and HLA-A*0201, and/or preventing its postoperative relapse; a method for inducing an immune response against a malignant tumor. A screening method for a peptide with the CTL induction property is disclosed.
EFFECT: present invention may find further application in immunotherapy of tumors associated with KNTC2.
13 cl, 4 dwg, 1 tbl
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