PEPTIDE VACCINES FOR CANCER EXPRESSING MPHOSPH1 OR DEPDC1 POLYPEPTIDES Russian patent published in 2012 - IPC C07K14/435 C07K7/00 C12N15/63 A61K38/00 A61K39/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to biotechnology and specifically to an isolated decapeptide or nonapeptide, capable for inducing cytotoxic T cells, as well as said peptides in which 1 amino acid is substituted, a polynucleotide which codes said peptides, a pharmaceutical composition and a vaccine, which contain said peptides, a method of inducing antigen-presenting cells, a method of inducing cytotoxic T cells, an isolated cytoxic CD8+ T cell, a dendritic cell which induces CTL and a method of treating a disease associated with high expression of SEQ ID NO: 1, 3 and/or 5 genes. The isolated decapeptide or nonapeptide, which is capable of inducing cytotoxic T cells, contains amino acid sequences selected from a group consisting of SEQ ID NO: 7, 8, 12, 9, 10, 11, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 253, 254 and 255. The pharmaceutical composition for treating a disease associated with high expression of SEQ ID NO: 1, 3 and/or 5 genes contains one or more said peptides and a pharmaceutically acceptable carrier. The method of treating a disease associated with high expression of SEQ ID NO: 1, 3 and/or 5 genes in an individual involves administering to the said individual a vaccine containing one or more said peptides.

EFFECT: invention enables to obtain peptides which are used to treat a disease associated with high expression of SEQ ID NO: 1, 3 and/or 5 genes.

22 cl, 26 dwg, 7 tbl, 2 ex