TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION AND USE THEREOF AS MEDICINAL AGENTS Russian patent published in 2013 - IPC C07D487/04 A61K31/5025 A61P7/02 

Abstract RU 2499797 C2

FIELD: chemistry.

SUBSTANCE: described are novel triazolopyridazines of general formula , stereoisomeric or tautomeric forms thereof and physiologically acceptable salts thereof, where Q1 denotes H, -C1-6alkyl, optionally substituted with fluorine, or -C3-6cycloalkyl; Q2 and Q3 independently denote H, -C1-6alkyl; R1-R3 independently denote H, -C1-6 alkyl, -C3-6cycloalkyl, -O-C3-6cycloalkyl, -O-C1-8alkyl, a heterocyclic residue etc; R4-R8 independently denote H, -C1-6 alkyl, -OH, -O-C1-8 alkyl, halogen, SF5 etc, a method for production thereof and use as medicinal agents.

EFFECT: compounds have antithrombotic activity and particularly inhibit the protease-activated receptor.

6 cl, 2 tbl, 242 ex

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RU 2 499 797 C2

Authors

Khajnel'T Uve

Vener Fol'Kmar

Kherrmann Mattias

Shenafinger Karl

Shtajnkhagen Khenning

Shajper Bodo

Dates

2013-11-27Published

2009-01-23Filed