SUBSTITUTED METHYLPHENYL KETONES SUITABLE FOR USE AS PDE4 INHIBITORS Russian patent published in 2013 - IPC C07D213/61 C07D413/12 C07D417/12 A61K31/44 A61K31/4427 A61P25/00 A61P29/00 A61P31/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of formula I , in which X₁, X₂, X₃, X₄ and X₅ independently denote -CH- or N; or X₃, X₄ and X₅ independently denote -CH- or N, and X₁ and X₂ independently denote C and are part of an additional 6-member aromatic ring; in which R₁ denotes methyl or ethyl, or R₁ denotes hydrogen; R₂ denotes methyl, ethyl, propyl, tert-butoxy carbonylmethyl, allyl, difluoromethyl, ethylbenzene, methylbenzene, butenyl, hydroxyethyl, tolyl, pentenyl, methoxyethyl, butynyl, propynyl, methylcarbonyloxy, cyclopentyl, each of which can be substituted with one or more identical or different substitutes selected from R₅; or R₂ denotes hydrogen; R₃ denotes alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, halogenalkyl, hydroxyalkyl, heterocycloalkenyl, alkylaryl, arylalkyl, alkylalkoxycarbonyl, alkylcarbonyloxy or alkoxyalkyl, each of which can be substituted with one or more identical or different substitutes selected from R₆; or R₃ denotes hydrogen, -CH₂-C(O)-heterocycloalkyl or -CH₂-C(O)NR₉-R₁₂; R₁₁ denotes one or more identical or different substitutes selected from hydrogen, halogen, cyano, amino, alkyl, methylthionyl, methylsulphonyl, amino, cyano or alkoxy; where R₅, R₆, R₉, R₁₂ are as indicated in claim 1, under the condition that R₁, R₂ and R₃ cannot be methyl at the same time; under the condition that when R₂ and R₃ both denote hydrogen, R₁ cannot be methyl or hydrogen; under the condition that when R₁ denotes methyl or hydrogen, R₂ denotes methyl and R₃ denotes hydrogen when ring B cannot be phenyl; and pharmaceutically acceptable salts and N oxides thereof. The invention also describes a pharmaceutical composition for use in case of skin diseases, said composition containing a compound of formula I, and use of said compound in preparing a medicinal agent for preventing conditions associated with skin wounds.

EFFECT: novel compounds which can be useful in treating skin diseases are obtained and described.

19 cl, 304 ex