METHOD FOR PREDICTION OF SUCCESS RATE OF INFECTIOUS COMPLICATION PREVENTION IN PREMATURE INFANTS Russian patent published in 2013 - IPC G01N33/00 G01N37/00 A61K35/00 

FIELD: medicine.

SUBSTANCE: disadvantages of the known methods are the absence of usage data in premature infants, including for the purpose of prevention, as well as a low accuracy degree. What is presented is predicting a success rate of the prevention of any infectious complications in premature newborns in the period of hospital nursing by taking into consideration the perinatal history, clinical-laboratory data, and by prescribing a probiotic. The above probiotic is a liguid form of E. faecium L3; the values of linear classification functions LCF₁ (the absence of infectious complications) and LCF₂ (the presence of infectious complications) are determined by formulas: LCF₁=-12.2-1.29X₁-0.27X₂-0.87X₃+4.75X₄+3.13X₅+10.68X₆, LCF₂=-8.78+0.74X₁+0.93X₂-0.15X₃+3.78X₄+ +2.77X₅+7.6X₆, wherein: X₁ - burdened maternal obstetric and gynecological history (0 - no; 1 - yes), X₂ - mother's chronic nicotine intoxification (0 - no; 1 - yes), X₃ - cesarean section (0 - no; 1 - yes), X₄ - high eosinophil count as shown by infant's complete blood count (0 - no; 1 - yes), X₅ - infant's feces Escherichia count by real-time polymerase chain reaction (1 - insufficient; 2 - normal; 3 - increased), X₆ - use of the probiotic form of E. faecium L3 in the integrated therapy of the premature infant (1 - no; 2 - yes); the LCF₁ and LCF₂ are compared, and the success rate is predicted if observing LCF₁>LCF₂.

EFFECT: using the declared method enables the more effective nursing of the premature infants, preventing the development of chronic diseases, reducing the number of unfavourable outcomes.

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