METHOD OF PREDICTING OUTCOME OF VIRAL ENCEFALITISES IN CHILDREN Russian patent published in 2009 - IPC A61B5/04 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to field of neuroinfectology and can be used for predicting outcomes of viral encephalitises in children. Carried out is complex estimation, including severity of clinical-neurological disorders, age of child in years, spread of pathological nidi on MRT, registration of somatosensory induced potentials (SSIP) on tibial nerve stimulation. Registration of somatosensory induced potentials is carried out on first days of disease and on 7-th day of disease with further calculation of linear-classification functions specific for favourable (LCF1) and unfavourable (LCF2) outcomes of encephalitis by formulas: LCF1=12.45+6.66*X1+1.97*X2+0.18*X3+1.21*X4+1.59*X5+2.91*X6 and LCF2= -22.85+8.18*X1+3.78*X2+0.25*X3+1.91*X4+1.9*X5+3.53*X6, where X1- severity of general state disturbance (0 or 1 point); X2 - severity of neurologic disorders (1-3 points); X3 - age of child in years; X4 - spread of pathological nidi on MRT (1-3 points); X5 - amplitude of cortical potential of SSIP in first days of disease (1-4 points); X6 - SSIP dynamics on the 7-th day of disease (1-4 points) and if LCF1>LCF2 favourable outcome of encephalitis with complete recovery of child in 6 months after disease onset, and if LCF2>LCF1 - unfavourable outcome of encephalitis with presence of nidal neurological symptoms of various degree of intensity in 6 months after disease onset.

EFFECT: method allows to increase accuracy of prognosis of encephalitis outcome in children and favours timely correction of the therapy and reduction of frequency of residual changes of CNS.

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