PHARMACEUTICAL COMBINATIONS OF ANGIOTENSIN RECEPTOR ANTAGONIST AND NEP INHIBITOR Russian patent published in 2014 - IPC C07D257/04 A61K31/216 A61P3/10 A61P9/10 C07F1/04 

Abstract RU 2503668 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a dual action compound which is characterised by general formula [((S)-N-valeryl-N-{[2'-(lH-tetrazol-5-yl)biphenyl-4-uyl]methyl}valine) ethyl ether (2R,4S)-5-biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid]Na1-3·xH2O, in solid form, where x equals 0-3, which is an angiotensin receptor inhibitor and a NEP inhibitor, and can be used to treat hypertension.

EFFECT: high efficiency of using the compound.

19 cl, 4 ex

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RU 2 503 668 C2

Authors

Fehn Lili

Godtfredsen Sven Ehrik

Karpinski P'Otr

Satton Pol Allen

Prashad Makhavir

Girgis Majkl Dzh.

Sjuj Bin'

Lju Jugan

Blehklok Tomas Dzh.

Dates

2014-01-10Published

2006-11-08Filed