COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY Russian patent published in 2014 - IPC C07D401/06 A61K31/4439 A61P29/00 

Abstract RU 2503672 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula

and a compound of general formula

,

where W is chlorine or fluorine, R1 is phenyl, optionally substituted with one or more halogen substitutes; and R4 is C1-C6alkyl, or pharmaceutically acceptable salts of said compounds. The invention also relates to a method of producing a compound of formula (II), use of compounds I and II to produce a drub for treating or preventing diseases such as asthma, allergic rhinitis and atopic dermatitis. Also described is a method of treating said diseases, as well as a pharmaceutical composition used to treat allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

EFFECT: novel compounds which can be used in treating allergic diseases such as asthma, allergic rhinitis and atopic dermatitis are obtained and described.

15 cl, 6 ex, 3 tbl

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RU 2 503 672 C2

Authors

Armer Richard Ehdvard

Pettifer Ehrik Roj

Vittaker Mark

Vajn Grekham Majkl

Vajl Dzhulija

Shroer Frehnk

Dates

2014-01-10Published

2009-01-19Filed