POLYMORPHOUS FORM OF [5-FLUORO-3-({2-[(4-FLUOROBENZENE) SULPHONYL]PYRIDIN-3-YL}METHYL)-2-METHYLINDOLE-1-YL]-ACETIC ACID Russian patent published in 2019 - IPC C07D401/06 A61K31/4439 A61P31/00

Abstract RU 2702343 C2

FIELD: chemistry.

SUBSTANCE: invention relates to polymorphous form of [5-fluoro-3-({2-[(4-fluorobenzene)sulphonyl]pyridin-3-yl}methyl)-2-methylindole-1-yl]-acetic acid, characterized by IR spectrum of c Fourier transform with characteristic peaks at 3068±2 cm^-1, 3054±2 cm^-1, 2976±2 cm^-1, 1582±2 cm^-1, 1427±2 cm^-1, 1298±2 cm^-1, 1213±2 cm^-1, 1190±2 cm^-1, 1164±2 cm^-1, 1060±2 cm^-1, 956±2 cm^-1, 927±2 cm^-1, 834±2 cm^-1, 700±2 cm^-1, 502±2 cm^-1, 421±2 cm^-1, 401±2 cm^-1, 388±2 cm^-1, 363±2 cm^-1, 353±2 cm^-1, 301±2 cm^-1, 208±2 cm^-1, 116±2 cm^-1, methods for its preparation and use as an agent for treating and preventing CRTH2-mediated diseases.

EFFECT: declared form has higher solubility than other forms of said compound, and is suitable for producing stable pharmaceutical compositions.

13 cl, 19 dwg, 4 tbl, 8 ex

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RU 2 702 343 C2

Authors

Khilfiker Rolf

Grosse-Sender Katya

Dates

2019-10-08—Published

2015-05-01—Filed