HETEROCYCLIC COMPOUNDS AS CRTH2 RECEPTOR ANTAGONISTS Russian patent published in 2012 - IPC C07D471/14 A61K31/405 A61K31/4375 A61K31/56 A61P29/00 A61P11/00 A61P9/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I:

or a pharmaceutically acceptable salt thereof, in which: one of A, B, C and D denotes N, and the rest independently denote CH and C(R¹); m equals a whole number from 1 to 4; n equals a whole number from 0 to 4; R¹ denotes halogen; R² and R³ denote hydrogen; R⁴ is selected from H, C_1-6alkyl; Ar denotes aryl, optionally substituted with one or more halogen atoms; X denotes -C(R^a)(R^b)-, where R^a and R^b denote H; Y denotes -S(O)₂-. The invention also relates to a pharmaceutical composition having CRTH2 receptor antagonist properties and containing a compound of formula I, to use of a compound of formula I when producing a drug for treating or preventing CRTH2 mediated diseases and a method for antagonistic action on CRTH2 receptor in mammals.

EFFECT: novel compound, which can be useful as a CRTH2 receptor antagonist, is obtained and described.

16 cl, 6 ex, 2 tbl