FUSED PROTEIN OR PEPTIDE WITH INCREASED HALF LIFETIME IN VIVO, WHICH IS MAINTAINED DUE TO SLOW RELEASE IN VIVO, AND METHOD FOR INCREASING HALF LIFETIME IN VIVO USING IT Russian patent published in 2014 - IPC C07K14/475 C07K14/81 C07K19/00 C12P21/02 

FIELD: biotechnologies.

SUBSTANCE: physiologically active protein or polypeptide are fused with version of alpha-1-antitrypsin, which has at least one mutated aminoacid residue. Mutations are performed in the following positions: asparagine residue instead of proline residue in position 357; or asparagine residue instead of proline residue in position 357 and threonine residue instead of serine in position 359; or asparagine residue instead of proline residue in position 357 and serine residue instead of cysteine in position 232; or asparagine residue instead of proline residue in position 357, threonine residue instead of serine in position 359 and serine residue instead of cysteine in position 232.

EFFECT: invention allows increasing half lifetime of physiologically active protein or polypeptide in vivo by maintaining its stable circulation in blood.

7 cl, 13 dwg, 7 ex