FIELD: biotechnology; medicine.
SUBSTANCE: invention relates to biotechnology, specifically an antigen-binding fragment (Fab) for serum albumin (SA), which can be used in medicine. Antigen-binding fragment (Fab) and a hybrid structure from the antigen-binding fragment are obtained, which are used in a method for increasing expression in the soluble form of a biologically active protein, and also in a method for increasing the half-life of a biologically active protein.
EFFECT: invention makes it possible to increase the half-life of serum and expression in the soluble form of the effector component.
24 cl, 22 dwg, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODY MOLECULES POSSESSING SPECIFICITY WITH RESPECT TO HUMAN TUMOR NECROSIS FACTOR-ALPHA AND THEIR USING | 2001 |
|
RU2303604C2 |
| COMPOSITION AND METHOD FOR IMMUNISATION, METHOD OF PRODUCING UNNATURAL, ORDERED AND REPEATING MASSIVE OF ANTIGENS | 2002 |
|
RU2438701C2 |
| COMPOSITION AND IMMUNIZATION METHOD, METHODS FOR PRODUCING NON-NATURAL, ORDERED AND REPEATED ANTIGEN MASSIVE AND COAT PROTEIN | 2002 |
|
RU2295973C2 |
| COMPOSITION AND METHOD FOR IMMUNIZATION, METHOD FOR PRODUCING OF NON-NATURAL, ORDERED AND REPEATED ANTIGEN MASSIVE | 2002 |
|
RU2294211C2 |
| VARIABLE DOMAINS OF LIGHT AND HEAVY CHAIN OF MURINE MONOCLONAL ANTIBODY AGAINST TUMOUR NECROSIS FACTOR ALPHA (TNF-α) OF HUMAN BEING (VERSIONS); ANTIGEN-BINDING FRAGMENT (Fab) AGAINST TNF-α OF HUMAN BEING, WHICH CONTAINS ABOVE SAID DOMAINS (VERSIONS) | 2012 |
|
RU2499000C1 |
| MODIFIED SIGNAL PEPTIDE OF ESCHERICHIA COLI ENTEROTOXIN-II AND MICROORGANISM EXPRESSING FUSION PROTEIN OF MENTIONED PEPTIDE WITH HETEROLOGICAL PROTEIN | 1999 |
|
RU2198179C2 |
| RECOMBINANT DNA MOLECULE ENCODING OF MODIFIED SWINE FACTOR VIII (POL1212), EXPRESSION VECTORS, MODIFIED SWINE FACTOR VIII, THERAPEUTIC COMPOSITION, METHODS FOR PRODUCTION OF MODIFIED SWINE FACTOR VIII PROTEIN (VARIANTS) AND CELL LINES (VARIANTS) | 2001 |
|
RU2285724C2 |
| RECOMBINANT ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF), OBTAINED BY VARIABLE REGION MUTAGENESIS | 2011 |
|
RU2557309C2 |
| PROTEIN COMPLEX, OBTAINED BY USING FRAGMENT OF IMMUNOGLOBULIN, AND METHOD OF SUCH COMPLEX OBTAINING | 2004 |
|
RU2356909C2 |
| IMMUNOGLOBULINS | 2005 |
|
RU2404192C2 |
