FIELD: biotechnologies.
SUBSTANCE: in formula
each of R1 and R2 independently represents H or C1-6alkyl; or R1 and R2 together form C3-6cycloalkyl circle, which is optionally replaced with one or more R2'; R2' represents C1-6alkyl, hydroxy group, halogen, amino group, C1-6alkoxy group, C1-6hydroxyalkyl or C1-6haloalkyl; R3 represents H or N(R4)(R5); R4 represents H, C1-6alkyl or C(=O)OR4'; R4' and R5 represents H or C1-6alkyl; represents H or C1-6alkyl; or R2 and R3 together form 5-membered heterocycle containing 1 atom of N in the amount of heteroatom, which is optionally replaced with one or more R2'; Q represents CH or N; Z1 represents (CH2)u; u and v mean 1; Z2 represents (CH2)v; m, n, p, r, q mean 0; Y1 represents CH(Y1'); Y1' represents H or C1-6alkyl; Y2 represents H or represents C1-6alkyl. Invention also refers to compounds of structural formulae (II), (IV) and to pharmaceutical composition containing the above compounds.
EFFECT: improving inhibiting activity in relation to JNK kinase.
10 cl, 4 tbl, 23 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2-AMINO-PYRIMIDINE DERIVATIVES AS JNK INHIBITORS | 2011 |
|
RU2572247C2 |
| NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS | 2009 |
|
RU2507202C2 |
| SUBSTITUTED PYRIMIDINES AND USE THEREOF AS JNK MODULATORS | 2007 |
|
RU2493155C2 |
| BRUTON'S TYROSINE KINASE INHIBITORS | 2010 |
|
RU2542585C2 |
| NOVEL PYRIDINONES AND PYRIDAZINONES | 2009 |
|
RU2505538C2 |
| PHOTOCHEMICALLY ACTIVE POLYMER MATERIALS | 2011 |
|
RU2592545C2 |
| 4-AMINOPYPERIDINE DERIVATIVES | 2005 |
|
RU2396257C2 |
| JAK INHIBITORS | 2010 |
|
RU2538204C2 |
| DERIVATIVES OF 1,1-DIOXOTHIOMORPHOLINYLINDOLYL METHANONE FOR USE AS HISTAMINASE MODULATORS | 2006 |
|
RU2412182C2 |
| NOVEL IMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY, AND USE THEREOF | 2017 |
|
RU2702749C1 |
