FIELD: chemistry.
SUBSTANCE: invention relates to compounds of structural formula I
having JNK inhibiting activity. In formula I m, n, p equals 0; X is CH or N; R3 is: C1-6alkylsulphonyl-C1-6alkyl or tetrahydrothiophenyl-1,1-oxide-C1-6alkyl; R5 is a group of formula (a) 
or (b) 
where q equals 0 or 1; r equals 0 or 1; Y is: NR9 or CR10R11; each of R6 and R7 is independently: hydrogen, a carboxy group, carboxy-C1-6alkyl ether or C1-6alkyl, or R6 and R7 together form a C1-2alkylene group; R8, R9,
R10 is: hydrogen or C1-6alkyl; and R11 is hydrogen, C1-6alkoxy group, NH2C(O)-, C1-6alkyl, hydroxy-C1-6alkyl, carboxy group, carboxy-C1-6alkyl, carboxy-C1-6alkyl ether or carboxy-C1-6alkyl-C1-6alkyl ether.
EFFECT: obtaining compounds having JNK inhibiting activity.
13 cl, 1 tbl, 25 ex
| Title | Year | Author | Number |
|---|---|---|---|
| JNK INHIBITORS | 2009 |
|
RU2504545C2 |
| IMIDAZOPYRAZINES | 2012 |
|
RU2600327C2 |
| HETEROCYCLIC SUBSTITUTED PHENYLMETHANONES AS GLYCINE TRANSPORTER 1 INHIBITORS | 2006 |
|
RU2405771C2 |
| SUBSTITUTED PYRIMIDINES AND USE THEREOF AS JNK MODULATORS | 2007 |
|
RU2493155C2 |
| PYRAZOLO[1,5-a]PYRIMIDINE AND THIENO[3,2-b]PYRIMIDINE DERIVATIVES AS MODULATORS OF IRAK-4 | 2011 |
|
RU2604062C2 |
| INDOLE-2-CARBOXAMIDES AS INHIBITORS OF FACTOR Xa AND/OR VIIa, MEDICINAL AGENT BASED ON THEREOF AND METHOD FOR THEIR PREPARING | 2002 |
|
RU2299881C2 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITION OF CATHEPSIN S ACTIVITY | 2001 |
|
RU2278863C2 |
| BENZOYLPIPERIDINE DERIVATIVES AS 5HT AND D RECEPTOR MODULATORS | 2007 |
|
RU2396265C2 |
| USE OF IBAT INHIBITOR FOR TREATING AND PREVENTING CONSTIPATION | 2008 |
|
RU2482850C2 |
| POSITIVE ALLOSTERIC MODULATORS (PAM) | 2010 |
|
RU2561920C2 |
