ETHYNYL INDOLE COMPOUNDS Russian patent published in 2014 - IPC C07D209/18 A61K31/404

Abstract RU 2505531 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel ethynyl indole compound of formula (I) , where: R¹ stands for carboxymethyl, 3-carboxypropyl; R² stands for H, C1-4 alkyl; R³ stands for [1-(carboxymethyl)cyclopropyl]methyl, 3-carboxypropyl; R⁴ stands for H, halogen; ring 1 stands for: , where R⁵ stands for C1-4 alkyl, halogen; m equal 0-5; R⁵ can be similar or different, when m equals 2 and more, and arrow stands for bond with butyloxy group; compounds demonstrate antagonistic activity with respect to cysLT₁/cysLT₂ receptor, which makes it possible to use them in pharmaceutical composition.

EFFECT: improvement of compound.

8 cl, 5 tbl, 6 dwg, 68 ex

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RU 2 505 531 C2

Authors

Okhmoto Kazujuki

Itadani Satosi

Nakajama Esisuke

Takeuti Dzun

Fudzita Manabu

Dates

2014-01-27—Published

2009-12-21—Filed