NOVEL CRYSTALLINE FORMS OF 4,4'-[4-FLUORO-7({4-[4-(3-FLUORO-2-METHYLPHENYL)BUTOXY]PHENYL} ETHYNYL)-2-METHYL-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID, 4,4'-[2-METHYL-7-({4-[4-(PENTAFLUOROPHENYL)BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID AND 4,4'-[4-FLUORO-2-METHYL-7-({4-[4-(2,3,4,6-TETRAFLUOROPHENYL) BUTOXY]PHENYL} ETHYNYL)-1H-INDOLE-1,3-DIIYL]DIBUTANOIC ACID Russian patent published in 2015 - IPC C07D209/18 A61K31/405 A61P11/06 A61P37/08 A61P43/00 

Abstract RU 2560147 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel crystalline forms of 4,4'-[4-fluoro-7-({4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl}ethynyl)-2-methyl-1H-indole-1,3-diiyl]dibutanoic acid, 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid and 4,4'-[4-fluoro-2-methyl-7-({4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diiyl]dibutanoic acid.

EFFECT: obtaining novel compounds.

18 cl, 16 dwg, 7 tbl, 24 ex

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RU 2 560 147 C2

Authors

Takehuti Dzjun

Itadani Satosi

Uehda Dzjunja

Ono Sidzuka

Nehkado Takakhiro

Fudzita Manabu

Dates

2015-08-20Published

2011-06-20Filed