INCLUSION COMPLEX OF DISULFIRAM AND CYCLODEXTRIN Russian patent published in 2016 - IPC C08L5/16 C08B37/16 

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry and deals with inclusion complex of disulfiram (DSF) and cyclodextrin (CD), selected from a group consisting of unsubstituted cyclodextrin (uCD) or substituted cyclodextrin, such as methylcyclodextrin (MCD), dimethylcyclodextrin (DMCD), trimethylcyclodextrin (TMCD) and hydroxypropylcyclodextrin (HPCD) produced by the method, in which CD, taken in a solid or dissolved in water or alcohol form, when stirred at a temperature from 20 to 70 °C is combined with DSF in the form of a solid substance, fusion or alcohol solution, where alcohol is selected from methanol, ethanol, n-propanol or iso-propanol, where molar ratio of CD and DSF ranges from 2.01:1 to 2.40:1. Obtained mixture is cooled to 0-25 °C, subjected to sterilising filtration and lyophilized, or solvent is evaporated.

EFFECT: reception of water-soluble inclusion complex of disulfiram with cyclodextrin, which can be extracted with high degree of purity.

1 cl, 5 dwg, 2 tbl, 8 ex