FIELD: medicine.
SUBSTANCE: microspheres contain diclofenac in the form of an acid included in a matrix of a biodegradable polymer specified in a group consisting of polylactide and polylactide-co-glycolide; an average size of microspheres falls within the range of 5 to 150 mcm; a degree of diclofenac inclusion makes 5-50%, and the said microspheres release 60 to 95% diclofenac for 14 days.
EFFECT: extended range of methods for preparing injectable agents for treating inflammatory conditions, such as rheumatoid arthritis, osteoarthritis and rheumatoid spondylitis characterised by the prolonged diclofenac release.
4 cl, 3 dwg, 1 tbl, 3 ex
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