METHOD FOR PREDICTION OF CLINICAL OUTCOME OF CHEMORADIATION THERAPY OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: immunoenzymometric analysis of blood serum TIMP-1 and TIMP-2 is combined with determining a primary tumour size according to the TNM classification, a degree of tumour differentiation, aging the patient and calculating a discriminant functions from the equations: Y1=-138.748+X1*15.963+X2*(-4.803)+X3*0.018+X4*2.319+X5*1.188 Y2=- 159.5454-X1*17.918+X2*(-4.266)+X3*0.028+X4*2.427+X5*1.242, wherein X1 is the primary tumour size according to the TNM classification, X2 is the degree of tumour differentiation, X3 is blood serum TIMP-1, ng/ml, X4 is a patient's age, years old; X5 is blood serum TIMP-2, ng/ml. If Y1>Y2, a high probability of the favourable outcome of the chemoradiation therapy is predicted. If Y1<Y2, a probability of no effect of the chemoradiation therapy is predicted.

EFFECT: more accurate, informative and effective treatment of the patients suffering malignant new growths of the head and neck.

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