METHOD FOR PREOPERATIVE RISK PREDICTION OF LYMPHOGENIC METASTASIS IN STAGE T1 ENDOMETRIAL CANCER Russian patent published in 2019 - IPC A61B5/55 A61K49/06 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, gynecology and radiodiagnosis, and can be used for preoperative prediction of risk of lymphatic metastasis in patients with endometrial adenocarcinoma T1 stage. Magnetic resonance imaging (MRI) of pelvic organs is performed to determine depth of tumour invasion into myometrium, tumour spread beyond the uterine body, size of lymph nodes. Additionally, preoperative MRI data are used to determine tumour volume, uterus wall thickness and its transition zone, as well as tumour histology - its degree of differentiation. These values are evaluated in scores (b) for calculating discriminant functions Y1 and Y2 by formulas Y1 = -11.2 + 2.98 * X1 + 2.1 * X2 + 1.9 * X3 + 7.2 * X4 + (- 0.38) * X5 + 1.5 * X6 and Y2 = -19.86 + 4.5 * X1 + 2.96 * X2 + (- 0.1) * X3 + 11.4 * X4 + (- 0.9) * X5 + 2.2 * X6. X1 is tumour volume in cm³, where X1 = 1b with tumour volume less than 25 cm³, X1 = 2b with tumour volume more than 25 cm³. X2 is endometrial tumour invasion, where X2 = 0b in the absence of invasion, X2 = 1b with tumour invasion less than myometrium thickness, X2 = 2b with thickness of tumour invasion more thickness of myometrium, X2 = 3b in case of tumour invasion to serous layer, X2 = 4b when spreading the tumour beyond the serous layer. X3 is uterine wall thickness, where X3 = 1b with a uterine wall thickness of less than 16 mm, X3 = 2b with a uterine wall thickness greater than or equal to 16 mm. X4 is thickness of transition zone, where X4 = 1b at thickness of transition zone is less than 8 mm, X4 = 2b at thickness of transition zone more or equal to 8 mm. X5 - maximum size of lymph nodes, where X5 = 1b with maximum size of lymph nodes of less than 10 mm, X5 = 2b with maximum size of lymph nodes of more than 10 mm. X6 is degree of tumour differentiation, where X6 = 1b with highly differentiated, X6 = 2b at moderately differentiated, X6 = 3b at low-grade, X6 = 4b at undifferentiated, X6 = 5b at a combination of high and moderate degree of differentiation of tumour, X6 = 6b at combination of low and moderate degrees of tumour differentiation. If Y1> Y2, a high risk of lymphatic metastasis is predicted, and if Y1 <Y2, the risk is low.

EFFECT: method provides higher accuracy and information value of a method for prediction of risk of lymphogenic metastasis in patients with endometrial adenocarcinoma T1 stage due to calculation of discriminant functions Y1 and Y2 on the basis of MRI data and histological examination of tumour.

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