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(19)

(11)

2 506 257

(13)

(51)

IPC

C07D207/16(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

C07D405/12(2006-01-01)

C07D405/14(2006-01-01)

C07D409/04(2006-01-01)

C07D409/12(2006-01-01)

A61K31/4025(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011115111/04, 2009-09-08

(24)

Start date

2009-09-08

(22)

Actual filing date

2009-09-08

(45)

Published

2014-02-10

(72)

Inventor

Din TsintsziTszjan Nan'Lju Tszin'Tszun'Ross Tina MorganChzhan TszinChzhan Chzhumin

(73)

Holder

F.Khoffmann-Lja Rosh Ag

SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES Russian patent published in 2014 - IPC C07D207/16 C07D401/12 C07D403/12 C07D405/12 C07D405/14 C07D409/04 C07D409/12 A61K31/4025 A61P35/00

Abstract RU 2506257 C2

FIELD: chemistry.

SUBSTANCE: invention relates to substituted pyrrolidine-2-carboxamides of formula I or their pharmaceutically acceptable salts, where values X, Y, R₁, R₂, R₃, R₃, R₄, R₅, R₆ and R₇ are given in item 1 of the formula. Compounds can be used in pharmaceutical composition, inhibiting interaction of MDM2-p53.

EFFECT: compounds can be used as anti-cancer medications.

46 cl, 4 dwg, 347 ex

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RU 2 506 257 C2

Authors

Din Tsintszi

Tszjan Nan'

Lju Tszin'Tszun'

Ross Tina Morgan

Chzhan Tszin

Chzhan Chzhumin

Dates

2014-02-10—Published

2009-09-08—Filed