FIELD: chemistry.
SUBSTANCE: claimed invention relates to novel quinazolina derivatives, which have benzofurane substituent of formula: 
in which each of R1, R2, R5, R8, R9 and R10 represent H, R3 and R4 similarly represent alkoxy or methoxyethoxy group; R6 represents alkyl; R7 represents-C(O)NRaRb, and each of Ra and Rb independently represents H, alkyl, ethyl, substituted with diethylaminogroup, C3-C6cycloalkyl, or Ra and Rb together form cycloalkyl; Z represents N; X represents O, S or NR, where R represents H or alkyl.
EFFECT: invention relates to pharmaceutical composition, inhibiting KDR, based on said compounds, method of treating associated with angiogenesis disorder, representing cancer, age-related macular degeneration or chronic inflammatory disease, and method of inhibiting activity of growth factor of vessel endothelium.
18 cl, 6 ex
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