ENPP1 INHIBITORS AND METHODS OF MODULATING THE IMMUNE RESPONSE Russian patent published in 2023 - IPC C07D401/04 C07F5/02 C07F9/09 C07F9/165 C07F9/38 C07F9/40 A61K31/517 A61K31/519 A61K31/675 A61K31/69 A61P35/00 C12N9/99 C12Q1/42 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions includes an ENPP1 inhibitor of formula (VI) and a pharmaceutical composition based on it. In formula (VI), X is selected from , , , , and ; L is selected from -CH₂ - and -(CH₂)₂-; each of Z¹ and Z² is independently selected from CR¹ and N; each of Z³ and Z⁴ is independently selected from CR and N, where R is H; each R¹ is independently selected from H and alkenyl having 2 to 6 carbon atoms substituted with pyridine; each of R² and R⁵ is independently selected from H, OH, alkoxy containing from 1 to 6 carbon atoms, and halogen; each of R³ and R⁴ is independently selected from H, OH, alkoxy containing from 1 to 6 carbon atoms, halogen and amino; or R³ and R⁴ together with the carbon atoms to which they are attached form dioxane.

(VI)

EFFECT: compound of formula (VI) with inhibitory activity against ENPP1.

13 cl, 11 dwg, 4 tbl, 16 ex