FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology and specifically to production of human pancreatic polypeptide analogues and can be used in medicine. The disclosed analogues differ from native human pancreatic polypeptide by replacement of amino acids on one or more residues, wherein position 0 is provided with an additional amino acid which is Gly.
EFFECT: obtained analogues provide effective treatment and prevention of obesity or diabetes in a patient, and can also be effective in reducing appetite, reducing food intake or reducing calorie intake in a patient.
26 cl, 2 dwg, 2 tbl,1206 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODY AND DRUG CONJUGATES (ADC) AND ANTIBODY AND PRODRUG CONJUGATES (APDC) CONTAINING ENZYMATICALLY CLEAVABLE GROUPS | 2016 |
|
RU2751512C2 |
| ANTI-MET ANTIBODIES AND THEIR USE | 2017 |
|
RU2765267C2 |
| PREVENTION AND TREATMENT OF CEREBRAL AMYLOID ANGIOPATHY | 2008 |
|
RU2523894C2 |
| ORAL CARE PRODUCTS AND METHODS CONTAINING HYDROXYAPATITE-BINDING PROTEINS | 2016 |
|
RU2745996C2 |
| ORAL CARE PRODUCTS AND METHODS CONTAINING HLP | 2016 |
|
RU2759134C2 |
| LIQUID PHARMACEUTICAL FORMULATIONS OF PTH CONJUGATES | 2020 |
|
RU2817015C2 |
| INSULIN ANALOGUES | 2017 |
|
RU2769476C2 |
| METHOD FOR PRODUCTION OF AROMATIC AMINOACIDS USING BACTERIUM THAT EXPRESSES GENE ARO1 FROM YEAST | 2008 |
|
RU2408723C2 |
| RECOMBINANT STRAIN BASED ON ESCHERICHIA COLI, A METHOD OF ITS CONSTRUCTION AND USE | 2020 |
|
RU2813283C2 |
| REDUCED NICOTINE CONVERSION INTO NORNICOTINE IN PLANTS | 2015 |
|
RU2733837C2 |
