FIELD: biotechnologies.
SUBSTANCE: characterised is recombinant pseudo adenoviral particle based on human being adenovirus genome of the 5-th serotype and method of its use as a component for production of vaccine for influenza virus A of H1N1 subtype. Presented recombinant particle contains expressing cassette including SV40 polyadenylation signal and cytomegalovirus promoter with influenza virus haemagglutinin gene being included. As influenza virus haemagglutinin gene, haemagglutinin gene of strain A/California/07/2009(H1N1) is used with pre-optimised for expression in human being cells nucleotide sequence provided in SEQ NO:2. These inventions allow raising specific immunity to influenza virus A of H1N1 subtype by provision of overexpression of haemagglutinin gene of influenza virus A/California/07/2009(H1N1).
EFFECT: improvement of the method.
6 cl, 9 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT PSEUDO-ADENOVIRUS PARTICLE BASED ON GENOME OF HUMAN ADENOVIRUS OF SEROTYPE 5, PRODUCING INFLUENZA HEMAGGLUTININ OF STRAIN A/Brisbane/59/2007(H1N1) AND METHOD OF ITS USE | 2012 |
|
RU2523599C1 |
| STRAIN OF A RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN ADENOVIRUS GENOME OF SEROTYPE 5 Ad5-tetOFF-E3-HA125 SEROTYPE, CARRYING HAEMAGGLUTININ CONSENSUS GENE OF INFLUENZA VIRUS SUBTYPES H1, H2, H5 FOR PRODUCING INFLUENZA IMMUNOGENIC PREPARATIONS, METHOD FOR PRODUCING GENE | 2018 |
|
RU2713722C1 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS A OF H3N2 SUBTYPE AND METHOD OF ITS USE | 2012 |
|
RU2507258C1 |
| RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN BEING ADENOVIRUS GENOME OF 5-TH SEROTYPE, PRODUCING HAEMAGGLUTININ OF INFLUENZA VIRUS OF B/Brisbane/60/2008 STRAIN AND METHOD OF ITS USE FOR INDUCTION OF SPECIFIC IMMUNITY TO INFLUENZA VIRUS B | 2012 |
|
RU2507259C1 |
| EXPRESSION VECTOR BASED ON HUMAN ADENOVIRUS 5 SEROTYPE, INDUCING CROSS-PROTECTIVE IMMUNITY TO INFLUENZA A VIRUSES OF SUBTYPE H1, AND A PHARMACEUTICAL COMPOSITION BASED ON IT | 2023 |
|
RU2802753C1 |
| VACCINE AGAINST INFLUENZA TYPE A, INFLUENZA TYPE B AND COVID-19 | 2021 |
|
RU2751485C1 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| RECOMBINANT TRIVALENT INFLUENZA VACCINE | 2012 |
|
RU2485973C1 |
| UNIVERSAL ANTI-INFECTIOUS VACCINE | 2015 |
|
RU2618918C2 |
| METHOD FOR PRODUCTION OF RECOMBINANT PSEUDOADENOVIRUS PARTICLES CONCENTRATE, EXPRESSING HEMAGGLUTININ GENE OF INFLUENZA A/CALIFORNIA/07/2009(H1N1) | 2015 |
|
RU2614127C2 |
