FIELD: biotechnologies.
SUBSTANCE: pox virus of variolovaccine is proposed, which includes a defect F2L gene and a suicide gene. Pox virus has oncolytic activity. Besides, a reproduction method of such pox virus and its use for treatment of proliferative diseases or diseases with increased activity of osteoclasts is proposed.
EFFECT: improving compound application efficiency.
31 cl, 12 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| POX VIRAL ONCOLYTIC VECTORS | 2008 |
|
RU2557312C2 |
| POXVIRAL ONCOLYTIC VECTORS | 2008 |
|
RU2503717C2 |
| ONCOLYTIC VIRUS FOR IMMUNOLOGIC CONTROL POINT MODULATORS EXPRESSION | 2015 |
|
RU2696312C2 |
| RECOMBINANT VARIOLOVACCINE VIRUS STRAIN VV-NS1-dGF PRODUCING NS1 PARVOVIRUS H-1 PROTEIN AND HAVING ONCOLYTIC ACTIVITY ON HUMAN GLIOBLASTOMA | 2018 |
|
RU2692628C1 |
| M2-DEFECTIVE POXVIRUS | 2019 |
|
RU2819245C2 |
| COMBINATION OF ONCOLYTIC VIRUS WITH MODULATORS OF IMMUNOLOGICAL CONTROL POINTS | 2015 |
|
RU2705780C2 |
| RECOMBINANT STRAIN VV-GMCSF-Lact OF VACCINIA VIRUS, HAVING ONCOLYTIC ACTIVITY AND PRODUCING GRANULOCYTIC-MACROPHAGAL COLONY-STIMULATING FACTOR AND ONCOTOXIC LACTAPTIN PROTEIN | 2015 |
|
RU2604187C1 |
| RECOMBINANT STRAIN OF VV-GMCSF-S-Lact VACCINIA VIRUS, WITH ONCOLYTIC ACTIVITY, PRODUCING GRANULOCYTOR-MACROPHAGAL COLONY-STIMULATING HUMAN FACTOR AND SECRETED FORM OF LACTAPTIN ONCOTOXIC PROTEIN | 2016 |
|
RU2621861C1 |
| RECOMBINANT ONCOLYTIC STRAIN OF THE VACCINIA VIRUS L-IVP_ONCOB, CONTAINING GENES, ENCODING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN, CONSISTING OF EPITOPES OF ANTIGENS, HYPER EXPRESSING BY TUMOR CELLS IN BREAST CANCER | 2017 |
|
RU2678056C1 |
| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOQ VACCINIA VIRUS, CONTAINING GENES ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN OVARIAN CANCER | 2017 |
|
RU2678003C1 |
