FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology and relates to the recombinant oncolytic vaccinia virus L-IVP_oncoB deposited in the State collection of pathogens of viral infections and rickettsial diseases of FBIS SSC VB "Vector" of Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing under number V-796. Proposed strain contains: A34R gene with two nucleotide substitutions; in the region of the viral thymidine kinase gene, the gene encoding granulocyte-macrophage colony-stimulating factor; in the area of viral gene encoding viral growth factor, the gene encoding polyepitope immunogen. Polyepitope immunogen consists of epitopes of HER2, mammoglobin-A, NY-BR-1, hMena, hTERT, MUC-1 antigens.
EFFECT: presented strain can be used for the preparation of drugs used in the treatment of breast cancer.
1 cl, 5 dwg, 11 ex
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|---|---|---|---|
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RU2678060C1 |
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|
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RU2692628C1 |
