FIELD: biotechnology.
SUBSTANCE: invention relates to a recombinant oncolytic vaccinia virus L-IVP_oncoQ, deposited in the state collection of pathogens of viral infections and rickettsioses of Rospotrebnadzor State Research Center of Virology and Biotechnology ‘Vector’ under number V-798. Proposed strain contains the A34R gene with two nucleotide substitutions; in the region of the viral thymidine kinase gene, the gene encoding granulocyte macrophage colony-stimulating factor; in the area of viral gene encoding viral growth factor, gene encoding polyepitope immunogen. Polyepitope immunogen consists of epitopes p53, surviving, WT1, 5T4, OY-TES-1, SPAG9, hTERT, MUC-1.
EFFECT: presented strain can be used for the preparation of medicines used in the treatment of ovarian cancer.
1 cl, 5 dwg, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT ONCOLYTIC STRAIN OF THE VACCINIA VIRUS L-IVP_ONCOB, CONTAINING GENES, ENCODING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN, CONSISTING OF EPITOPES OF ANTIGENS, HYPER EXPRESSING BY TUMOR CELLS IN BREAST CANCER | 2017 |
|
RU2678056C1 |
| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOM VACCINIA VIRUS, CONTAINING GENES, ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN MELANOMA | 2017 |
|
RU2678060C1 |
| RECOMBINANT STRAIN VV-GMCSF-Lact OF VACCINIA VIRUS, HAVING ONCOLYTIC ACTIVITY AND PRODUCING GRANULOCYTIC-MACROPHAGAL COLONY-STIMULATING FACTOR AND ONCOTOXIC LACTAPTIN PROTEIN | 2015 |
|
RU2604187C1 |
| RECOMBINANT STRAIN VV-GMCSF-S1/3 OF VACCINIA VIRUS, PRODUCING SECRETED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING HUMAN FACTOR | 2013 |
|
RU2565544C2 |
| RECOMBINANT STRAIN OF VV-GMCSF-S-Lact VACCINIA VIRUS, WITH ONCOLYTIC ACTIVITY, PRODUCING GRANULOCYTOR-MACROPHAGAL COLONY-STIMULATING HUMAN FACTOR AND SECRETED FORM OF LACTAPTIN ONCOTOXIC PROTEIN | 2016 |
|
RU2621861C1 |
| RECOMBINANT OF VV-GMCSF / LACT-DGF VIRUS OF OSVOVICINE, OF ONLY-COLIC ACTIVITY AND PRODUCING SECRETABLE CHIMERIC WHITE, CONTAINING FROM GRANULOCYTE-MACROPHAGAL COLONISTIMULATING HUMAN FACTOR AND ONCOTOXIC PROTEIN OF LACTAPTIN | 2016 |
|
RU2630672C1 |
| RECOMBINANT PLASMID DNA pGEM-Puro-DS-Apo COMPRISING SYNTHETIC APOPTIN GENE FLANKED BY SEQUENCES OF VACCINIA VIRUS GENOME OF ISLAND C10L-C12L, AND RECOMBINANT STRAIN VVdGF-ApoS24/2 OF VACCINIA VIRUS PRODUCING APOPTIN | 2012 |
|
RU2492238C1 |
| RECOMBINANT STAIN OF VACΔ6 VACCINIA VIRUS WITH BROKEN GENES OF VIRALENCE C3L, N1L, J2R, A35R, A56R, B8R FOR THE PRODUCTION OF LIVE CULTURAL ATTENUATED VACCINE AGAINST NATURAL SMALLPOX AND OTHER ORTHOPOXVIRAL HUMAN INFECTIONS | 2016 |
|
RU2621868C1 |
| RECOMBINANT STRAIN L-IVP 1421ABJCN POX VIRUS VIRULENCE GENES WITH BROKEN A56R, B8R, J2R, C3L, N1L FOR PRODUCING LIVE CULTURE OF ATTENUATED SMALLPOX VACCINE AND OTHER ORTHOPOXVIRUSES, PATHOGENIC FOR HUMANS | 2015 |
|
RU2588388C1 |
| RECOMBINANT VARIOLOVACCINE VIRUS STRAIN VV-NS1-dGF PRODUCING NS1 PARVOVIRUS H-1 PROTEIN AND HAVING ONCOLYTIC ACTIVITY ON HUMAN GLIOBLASTOMA | 2018 |
|
RU2692628C1 |
