BIOCOMPATIBLE, BIODEGRADABLE COMPOSITE FIBRE AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2014 - IPC C08L5/00 B82B3/00 

FIELD: chemistry.

SUBSTANCE: method of producing fibre involves mixing hydrosilicate filler, which is pre-dispersed in an aqueous medium with pH 5-7 in an ultrasonic field with frequency v=20-100 kHz for 5-60 minutes, with chitosan in an amount which corresponds to concentration thereof in the solution of 1-4 wt %. The amount of the filler is 0.05-2% of the mass of the chitosan. The obtained mixture is intensely stirred at temperature of 20-50°C for 20-60 minutes. Concentrated acetic acid is then added in an amount which enables to obtain aqueous acetic acid solution with concentration of 1-8 wt % in the mixture. The mixture is intensely stirred at temperature of 20-50°C for 20-250 minutes. The mixture is filtered and deaerated. The fibre is formed through a draw plate into an alcohol or alcohol-alkaline precipitation agent, wherein the shear velocity of the solution in the plane of the cross-section of the capillary when the solution passes through the draw plate is selected in the range of 1.0-10^-3 s^-1. The fibre is stretched by 10-120%, washed with water and dried at temperature of 20-50°C. The fibre contains chitosan and hydrosilicate filler - halloysite, chrysotile, montmorillonite - in form of nanoparticles in amount of 0.05-2% of the mass of chitosan. The fibre has a single-phase homogeneous structure which corresponds to the basic form of chitosan.

EFFECT: obtaining a biocompatible, biodegradable composite elastic and strong fibre based on chitosan for use in medicine and biotechnology, particularly in suture filaments and in cellular engineering.

2 cl, 3 dwg, 8 ex