NANOFIBRE-BASED COMPOSITE POLYMERIC WOUND COATING Russian patent published in 2018 - IPC A61F13/51 B82B3/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the chemistry of macromolecular compounds, specifically to composite polymer wound coatings based on nanofibres. Invention is intended for use in medicine, veterinary medicine and pharmacology as wound coatings, in tissue engineering – as matrices for cellular technologies, as well as in regenerative medicine. Wound coating consists of two layers, the upper one of which is a porous film material with a pore size of 10–1,000 mcm, a thickness of 0.1–1 mm, based on nanofibers with diameter of 0.1–1 mcm made of a non-resorbable copolymer of ε-caprolactam and hexamethylene diamine adipate with a ratio of monomer units of 60:40 to 40:60 wt%, and the lower layer, intended for direct contact with the wound, with a thickness of 0.1–1 mm with a pore size of 10–500 mcm is based on composite nanofibers with diameter of 0.1–0.5 mcm from a resorbable chitosan polymer with a degree of deacetylation of 70–95 %, molecular weight of 150–400 kDa containing 0.1–30 wt% of resorbable chitin nanofibrils with transverse size of 15–20 nm and longitudinal size of 400–500 nm as filler.

EFFECT: wound coatings are biocompatible, durable and at the same time elastic in biologically active media, provide steam and gas exchange in contact with the wound surface, are atraumatic, layer adjacent to the wound undergoes complete bioresorption for several weeks, the products of bioresorption are non-toxic.

1 cl, 2 tbl, 4 dwg