ANTIBACTERIAL INJECTABLE PHARMACEUTICAL COMPOSITION Russian patent published in 2014 - IPC A61K9/10 A61K31/7048 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to veterinary science and medicine, and may be used to prevent and treat bacterial infections. An antibacterial injectable pharmaceutical composition comprises azithromycin, solvents and/or co-solvents, a preserving agent, and an antioxidant. The antioxidant is presented by ascorbic acid, or sodium ascorbate, or calcium ascorbate, or palmityl ascorbate, or 4-methyl-2,6-ditertbutylphenol, or tertbutylhydroquinone, 2,4,5-trihydroxybutyrophenone, or sodium metabisulphite, or alpha tocopherol, or thioglycerol, or combinations thereof; the preserving agent is presented in the form of benzyl alcohol, parabenes, chloroethanol or combinations thereof; the solvents or co-solvents are organic solvents, including dimethylacetamide, or dimethylsulphoxide, or N-methyl-2-pyrrolidone, or 2-pyrrolidone, or combinations thereof, or combinations of organic solvents with water in the following relations, wt %: azithromycin 5-50, antioxidant 0.1-0.2, preserving agent 1-2, pH regulator up to 5, solvents the rest.

EFFECT: antibacterial injectable pharmaceutical composition of azithromycin possesses a wide spectrum of the antimicrobial action, and is applicable to the intravenous, intramuscular, subcutaneous, intrauterine and intracisternal introduction.

3 cl, 1 dwg, 7 tbl, 11 ex