DEVICE FOR LOCAL AND/OR REGIONAL DELIVERY USING LIQUID FORMULATIONS OF ACTIVE SUBSTANCES Russian patent published in 2014 - IPC A61M5/00 A61F2/82 A61K31/337 A61K31/436 A61P9/10 

FIELD: medicine.

SUBSTANCE: invention refers to medical devices, particularly to drug delivery devices. The device comprises an expandable element having an external surface contacting surrounding tissue. A liquid formulation of a therapeutically active substance is connected to the external surface. The liquid formulation contains rapamycin in a pharmacologically effective dosage, ethanol in a trough concentration of approximately 1.57 mass percent, vitamin E TPGS in an amount of approximately 6.55 mass percent and water in an amount of approximately 90.51 mass percent. The liquid formulation contains a finishing solution of rapamycin in a span of concentrations from approximately 4 mg/ml to approximately 15 mg/ml. The expandable element can represent, e.g. a stent.

EFFECT: device provides the local and regional delivery of the therapeutically active substances for inhibiting body reaction to introducing the device, thereby preventing thrombosis, treating restenosis, and atherosclerotic plaques in the patients suffering diabetes mellitus.

6 cl, 111 dwg, 23 tbl