FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to developing expandable medical devices, particularly stents, and can be used for treating restenosis in a vessel lumen. A presented implantable medical device involves intraluminal frame (IF) comprising a number of openings. The IF has a tubular configuration and comprises a number of cylindrical sections connected by the number of connective elements. Each of the cylindrical sections of the IF is formed of a mesh of elongated braces connected by plastic pivots and peripheral braces. Different openings of the IF are filled with at least two various therapeutic agents. At least one therapeutic agent filling one of the openings is incorporated into poly(lactic-co-glycolic acid) (PLGA) matrix to control a release rate and a cumulative released dose of the therapeutic agent into the surrounding tissue.
EFFECT: invention provides the effective combination therapy by using two or more drugs and/or active substances filling the different openings of the devices keeping its wall thickness the same with no limitation of its movement, as well as by enabling the drug delivery with various release kinetics and/or clearance period.
6 cl, 2 tbl, 3 ex
