PRIMER-ADHESION PROMOTER FOR SURFACES WITH COATING Russian patent published in 2014 - IPC A61F2/82 A61F2/91 A61F2/915 A61L31/10 A61L31/16 B05D7/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine. An implanted medical device for delivery of a number of medications to a place of intervention in accordance with the first version contains in fact a cylindrical intraluminal framework, a primer layer, the first and second coatings and, at least, one therapeutic preparation. The cylindrical intraluminal framework is expandable from the first diameter for delivery into a vessel to the second diameter for the vessel expansion. The intraluminal framework has a luminal surface and an abluminal surface. The distance between the luminal surface and the abluminal surface specifies a thickness of the intraluminal framework wall. The intraluminal framework also contains a multitude of holes, extending from the luminal to abluminal surface. The primer layer includes a multitude of layers and covers the luminal surface, the abluminal surface and surfaces of the multitude of holes. The first coating contains a material, which has the first electric charge, and is fixed to the primer layer. The second coating contains a material, which has the second electric charge and is fixed to the first coating only in the multitude of holes. The second electric charge is opposite to the first electric charge. The therapeutic preparation is placed in, at least, one of the multitude of holes. The second coating is made in the form of an intermediate layer between the first coating and, at least, one therapeutic preparation. The implanted medical device in accordance with the second version contains a cylindrical intraluminal framework, a layer of first coating, a layer of second coating and, at least, one therapeutic preparation. The cylindrical intraluminal framework is expandable from the first diameter for delivery into a vessel to the second diameter for the vessel expansion and has a luminal surface and an abluminal surface. The distance between the luminal surface and the abluminal surface specifies a thickness of the intraluminal framework wall. The intraluminal framework also contains a multitude of holes, extending from the luminal to abluminal surface. The first coating contains a material with the first electric charge, fixed on at least, a part of the abluminal surface, the luminal surface and surfaces of the multitude of holes. The layer of the second coating contains a material with the second electric charge, fixed on, at least, a part of the layer of the first coating. The second electric charge is opposite to the first electric charge. The therapeutic preparation is placed in, at least, one of the multitude of holes. The layer of the second coating is made in the form of an intermediate binding layer between the layer of the first coating and, at least, one therapeutic preparation, resulting in obtaining a layered configuration, in which the layer of the second coating is located between the layer of the first coating and, at least, one therapeutic agent, applied in, at least, one of the multitude of holes. The method of the coating application on the intraluminal framework, containing the multitude of holes, made in it, has the following stages: application of the layer of the first coating, containing the material, which has the first electric charge on, at least, a part of the surface of the intraluminal framework and the surface of the multitude of holes; application of the layer of the second coating, containing the material, which has the second electric charge, on, at least, a part of the first coating, with the second electric charge being opposite to the first electric charge; and application of, at least, one therapeutic preparation into, at least, one of the multitude of holes to form the layered configuration, in which the layer of the second coating is located between the layer of the first coating and, at least, one therapeutic agent, applied in, at least, one of the multitude of holes.

EFFECT: inventions ensure prevention of thrombosis and separation of the coating from the underlying surface of a stent.

13 cl, 11 dwg, 2 tbl