FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to an agent for DNA delivery into cells representing an alkyl ammonium geminal surfactant (GS) derivative of formula: 
, wherein m=4, 6, 12.
EFFECT: compounds are novel low-toxic compounds that provide an efficient DNA delivery into eukaryotic cells and can be used for therapeutic treatment by the intracellular delivery of genes of various human diseases.
6 dwg, 1 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THIACALIXARENE DERIVATIVES AS AGENT FOR DNA DELIVERY INTO CELLS | 2014 |
|
RU2551277C1 |
| ELECTROCHEMICAL METHOD FOR SYNTHESIS OF ORGANONICKEL SIGMA-COMPLEXES | 2009 |
|
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| TETRAMETHYLOXYPHENYL CALIX[4]ARENE DERIVATIVE FOR SORPTION OF AZO DYES FROM AQUEOUS SOLUTIONS | 2012 |
|
RU2480451C1 |
| HISTONES AND BIODEGRADABLE LIPIDES AS MEANS FOR NUCLEIC ACIDS DELIVERY TO EUKARYOTIC CELLS | 2015 |
|
RU2637371C2 |
| METHOD OF PRODUCING BINUCLEAR 3,4,5-TRIARYL-1,2-DIPHOSPHACYCLOPENTADIENIDE MANGANESE COMPLEXES | 2013 |
|
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| α,ω-BIS(AMIDE- AND HYDRAZIDE METHYL SULFINYL- AND SULPHONYL) ALKANES HAVING ANTI-TUBERCULOSIS ACTIVITY, AND α,ω-BIS(METHOXY CARBONYL METHYL SULFINYL- OR SULPHONYL) ALKANES FOR PRODUCTION THEREOF | 2015 |
|
RU2591256C1 |
| AGENT SHOWING ANTIVIRAL ACTIVITY ON DNA-VIRUSES | 2012 |
|
RU2487876C1 |
| METHOD OF PRODUCING FUNCTIONALISED SODIUM 3,4,5-TRIARYL-1,2-DIPHOSPHACYCLOPENTADIENIDES | 2012 |
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RU2487133C1 |
| POLYETHYLENE GLYCOL-CONTAINING LIPID, COMPOSITION BASIS THEREOF WITH CATIONIC AMPHIPHILIC AND NEUTRAL PHOSPHOLIPID AND METHOD FOR PREPARATION THEREOF FOR DELIVERING NUCLEIC ACIDS IN VIVO | 2017 |
|
RU2683572C1 |
| DIMEPHOSPHONE NICOTINOYLHYDRAZONE POSSESSING ANTI-TUBERCULOSIS ACTIVITY | 2011 |
|
RU2471787C1 |
