MACROMER WITH ISOCYANATE TERMINAL GROUP AND BASED ON IT COMPOSITION FOR APPLICATION AS GLUE OR SEALANT FOR INTERNAL APPLICATION Russian patent published in 2014 - IPC C08G18/77 C08G18/10 C08G18/42 A61L24/04 A61L17/10 A61L27/18 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to biocompatible polyisocyanate macromer or mixture of macromers for application as glue or sealant for internal application, represented by formula: , where f equals two or more; a in the range from 1 to 5 and R₁ represents , where d is in the range from 0 to 5 and c can be in the range from 1 to 100; R₂ represents , where R₃ represents linear or branched residue of water-soluble polymer, which forms ester bonds with R₄ and urethane bonds with R₁, when a equals one or more; and R₄ represents linear or branched organic residue, which contains two or more carboxylate terminal groups, and x gives the number of repeating R₄ and is in the range 2≤x≤6. Also described are biocompatible elastic gel, obtained by polymerisation of said macromer, composition, applicable for medicine, and method of internal wound closing.

EFFECT: creation of glue or sealant for internal application, preserving ability for manipulations and smoothing, which fills internal sinuses and empty spaces, penetrates and tightly fits cavities and pores of tissue before hardening or setting, and is biologically decomposable.

9 cl, 3 tbl, 3 ex