FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing N-substituted menthane carboxamides. The method is carried out via a coupling reaction between primary menthane carboxamides and aryl halides in the presence of a copper catalyst. The invention also relates to neoisomers having a 1S,2S,5R-configuration, menthane derivatives selected from menthyl esters, menthyl ethers, menthane carboxyl esters or menthane carboxamides, having cooling agent properties, as a product intended for oral application, containing an amount of a neoisomer sufficient to create a cooling sensation in the mouth, and a method of creating a cooling effect in the mouth.
EFFECT: improved method of producing menthane carboxamide derivatives with high output, neoisomers of menthane derivatives, having cooling agent properties.
18 cl, 4 ex
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