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2 466 130

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IPC

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

C07D235/18(2006-01-01)

A61K31/437(2006-01-01)

A61K31/519(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009128188/04, 2007-12-21

(24)

Start date

2007-12-21

(22)

Actual filing date

2007-12-21

(45)

Published

2012-11-10

(72)

Inventor

Berdini ValerioBezong Gilbert EhbajKallagan OuehnKarr Marija GratsijaKongriv Majlz StjuartDzhill Ehdrian LiehmGriffits-Dzhounz Sharlott MehriMehdin EhndrjuMjurrej Kristofer Uill'JamNidzhar Radzhdip KaurO'Brajen Majkl AlistehrPajk EhndrjuSaksti GordonTehjlor Richard DehvidVikerstaff Ehmma

(73)

Holder

Asteks Terap'Jutiks Limited

BICYCLIC HETEROCYCLIC COMPOUNDS AS FGFR INHIBITORS Russian patent published in 2012 - IPC C07D471/04 C07D487/04 C07D235/18 A61K31/437 A61K31/519 A61P35/00

Abstract RU 2466130 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new bicyclic heterocyclic derivatives of general formula wherein radicals and symbols are specified in the patent claim. Said compounds are FGFR receptor (fibroblast growth factor receptor) inhibitors. The invention also refers to a method for preparing a preferential group of compounds of formula (I), to a pharmaceutical composition containing said compounds, and to the use of said compounds for treating diseases, e.g. cancer.

EFFECT: preparing the new bicyclic heterocyclic derivatives.

22 cl, 16 tbl, 422 ex

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RU 2 466 130 C2

Authors

Berdini Valerio

Bezong Gilbert Ehbaj

Kallagan Ouehn

Karr Marija Gratsija

Kongriv Majlz Stjuart

Dzhill Ehdrian Liehm

Griffits-Dzhounz Sharlott Mehri

Mehdin Ehndrju

Mjurrej Kristofer Uill'Jam

Nidzhar Radzhdip Kaur

O'Brajen Majkl Alistehr

Pajk Ehndrju

Saksti Gordon

Tehjlor Richard Dehvid

Vikerstaff Ehmma

Dates

2012-11-10—Published

2007-12-21—Filed