4-ISOPROPYLPHENYLGLUCITE DERIVATIVES AS SGLT1 INHIBITORS Russian patent published in 2014 - IPC C07D309/10 C07D405/12 A61K31/351 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of 4-isopropylphenylglucite, which do not tend to accumulate in organism and which inhibit SGLT1 activity, suppressing postprandial hyperglycaemia (or impaired glucose tolerance) due to inhibition of glucose absorption in the small intestine, due to which compounds in accordance with claimed invention can, for instance, slow down development of diabetes or metabolic syndrome or treat said diseases. Said derivatives of 4-isopropylphenylglucite are represented by the following formula , where R¹ stands for hydrogen atom or C_1-4alkyl group, R² stands for hydrogen atom or methyl group, R³ stands for "C_1-4alkyl group, substituted with aminogroup(s) or di-C_1-4alkylaminogroup(s)" or piperidyl group, and R⁴ stands for hydrogen atom or, as an alternative, R³ and R⁴, together with nitrogen atom, to which they are bound, form piperidine group or piperazinyl group, which can be substituted with C_1-4alkyl group(s) or dimethylaminogroup(s) or are pharmaceutically acceptable salts of said compounds.

EFFECT: obtaining 4-isopropylphenylglucite derivatives.

7 cl, 3 tbl, 17 ex