FIELD: chemistry, pharmacology.
SUBSTANCE: group of inventions relates to insulin conjugate, possessing improved action duration and stability in vivo, obtained by covalent binding of insulin with Fc region of immunoglobulin via non-peptidyl polymer, as well as to composition of prolonged action, which contains it, and to method of their obtaining.
EFFECT: support of insulin activity in vivo at relatively high level and considerable increase of period of its serum half-life, with considerable increase of improvement of medication intake regimen in comparison with insulin therapy.
21 cl, 8 ex, 6 dwg
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