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(19)

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2 519 219

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IPC

A61L27/28(2006-01-01)

A61L27/20(2006-01-01)

A61L27/36(2006-01-01)

A61F2/24(2006-01-01)

(21) (22)

Application

2012156376/15, 2012-12-25

(24)

Start date

2012-12-25

(22)

Actual filing date

2012-12-25

(45)

Published

2014-06-10

(72)

Inventor

Chashchin Ivan SergeevichGalljamov Marat OlegovichKhokhlov Aleksej RemovichBakuleva Natalija PetrovnaKostava Vakhtang TengizovichLjutova Irina GennadievnaZalepugin Dmitrij Jur'EvichTil'Kunova Natalija AleksandrovnaChernyshova Irina Valer'EvnaGrigor'Ev Timofej Evgen'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Imeni M.V. Lomonosova"Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Tsentr Serdechno-Sosudistoj Khirurgii Imeni A.N. Bakuleva" Rossijskoj Akademii Meditsinskikh NaukFederal'Noe Gosudarstvennoe Unitarnoe Predprijatie Zavod Meditsinskikh Preparatov"Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Ehlementoorganicheskikh Soedinenij Im. A.N. Nesmejanova Rossijskoj Akademii Nauk"

BIOLOGICAL CHITOSAN COATED PERICARDIAL VALVE PROSTHESIS AND METHOD FOR MAKING IT Russian patent published in 2014 - IPC A61L27/28 A61L27/20 A61L27/36 A61F2/24

Abstract RU 2519219 C1

FIELD: medicine.

SUBSTANCE: what is described is a method for applying a chitosan coating on a pericardial surface of a biological heart valve prosthesis by direct chitosan application from a non-immunogenic solvent absolutely biocompatible with a human body and possessing antimicrobial properties, - high-pressure carbonated water, onto the pericardium of the biological heart valve prosthesis pre-processed with 0.625% glutaric aldehyde. The method for chitosan coating from high-pressure carbonated water enables providing higher effectiveness and prolonged functioning of the biological heart valve prosthesis ensured by avoiding formation of deposited calcium on the surface, providing better elasticity, enhancing antimicrobial properties enabled by the chitosan coating on the surface.

EFFECT: making the non-immunogenic calcification resistant biological heart valve prostheses possessing the antimicrobial properties.

12 cl, 1 dwg, 4 tbl, 12 ex

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RU 2 519 219 C1

Authors

Chashchin Ivan Sergeevich

Galljamov Marat Olegovich

Khokhlov Aleksej Removich

Bakuleva Natalija Petrovna

Kostava Vakhtang Tengizovich

Ljutova Irina Gennadievna

Zalepugin Dmitrij Jur'Evich

Til'Kunova Natalija Aleksandrovna

Chernyshova Irina Valer'Evna

Grigor'Ev Timofej Evgen'Evich

Dates

2014-06-10—Published

2012-12-25—Filed