METHOD FOR STERILISATION AND PRE-IMPLANTATION STORAGE OF BIOLOGICAL PROSTHESES OF XENOGENIC AND ALLOGENIC TISSUE FOR CARDIOVASCULAR SURGERY Russian patent published in 2012 - IPC A61L2/16 A61L27/00 A61K31/498 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely cardiovascular surgery and transplantation. A method involves exposition of bioprostheses in a sterilising solution presented by a solution of 2-3-bis(hydroxymethyl)quinoxaline-1,4-dioxide taken in the concentrations of 0.1 to 1.0% at pH 5.0 to 8.0, and temperature 16 to 40°C; the pre-implantation storage of bioprostheses of xenogenic tissues is performed in the same sterilising solution, while the bioprostheses of allogenic tissue are stored in a cryopreserving mixture.

EFFECT: invention provides the sterility of bioprostheses of allogenic and xenogenic biotissue, preserves their stress-strain properties and does not provoke cytotoxicity of biological tissue, as well as reducing biological prostheses preparation time for implantation considerably.

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