FIELD: chemistry.
SUBSTANCE: compounds can be applied for treatment of oncologic and autoimmune diseases. Invention also characterises method of obtaining conjugates, pharmaceutical composition and medication, which contains modified proteins. In general formulae 1 or 2 , R1 is selected from the group representing (CH3)2N-,
R2 is selected from the group representing where R3 as terminal substituent represents -NH2,
or and R4 represents H or C1-C3alkyl.
EFFECT: novel compounds possess affinity for CD16a receptor.
18 cl, 20 dwg, 3 tbl, 19 ex
Title |
Year |
Author |
Number |
TRICYCLIC DERIVATIVES, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND METHOD OF INHIBITION OF VASOPRESSINE |
1994 |
- Dzhej D. Olbrajt
- Mehrvin F. Rejch
- Fuk-Vakh Sam
- Ksjumej Du
|
RU2149160C1 |
METHOD OF PREPARING 5-SUBSTITUTED 10,11-DIHYDRO-7-5H-DIBENZO /A,D/ CYCLOHEPTENE-5,10-IMINES |
0 |
- Pol Stenli Anderson
- Marsia Elizabet Kristi
- Ben Edvard Evans
- Sandor Karadi
|
SU895288A3 |
TRICYCLIC DIAZEPINE VASOPRESSIN AND OXYTOCIN ANTAGONISTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
1994 |
- Dzhej D.Olbrajt
- Mehrvin F.Rejch
- Fuk-Vakh Sam
- Ehfren Gil'Ermo Delos Santos
|
RU2126006C1 |
N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF NEUROGENIC INFLAMMATION |
1995 |
- Knud Ehrik Andersen
- Uffe Bang Ol'Sen
- Khans Petersen
- Frederik Kristian Grenval'D
- Ursula Sonneval'D
- Tine Krog Jergensen
- Khenrik Sune Andersen
|
RU2167152C2 |
METHOD OF OBTAINING DERIVATIVES OF DIBENZOCYCLOHEPTENE, RACEMATE OR OPTICALLY ACTIVE SALTS THEREOF |
0 |
- Lyusen Nedelek
- Daniel Freshke
|
SU651704A3 |
AMINOACETIC ACID DERIVATIVES AS RACEMATES OR D-AND L- ENANTIOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD OF PREPARING D-AND L-ENANTIOMERS OF AMINOACETIC ACID DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND AMINOACETIC ACID D-AND L-ENANTIOMERS AS CINCHONIDINE SALTS |
1993 |
- Vladimir Bajlin[Ua]
- Khuaj Gu Chen[Us]
- Om Prakash Gel'[Us]
- Mark Judzhin Marlatt[Us]
- Dzhon Gordon Topliss[Us]
|
RU2111206C1 |
NOVEL SUBSTITUTED TETRACYCLIC DERIVATIVES OF TETRAHYDROPYRAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE |
2005 |
- Sid-Nun'Es Khose Marija
- Megens Antonius Adrianus Khendrikus Petrus
- Trabanko-Suares Andres Avelino
- Koukni Mokhamed
- Khornart Dzhorzh Zhozef Kornelius
- Kompernolle Frans Jozef Kornelius
- Kozletski Tomash
- Mao Khua
- Dzhkha Sushil Chandra
- Fernandes-Gadea Fransisko Khav'Er
|
RU2401257C2 |
SUBSTITUTED DIHYDRODIBENZO[B,F]AZEPINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIEPILEPTIC ACTIVITY |
1996 |
- Zhan Benes
- Patrisio Manuehl V'Ejru Arauzho Suarish Da Silva
|
RU2168502C2 |
NON-STEROIDAL MODULATORS OF PROGESTERONE RECEPTOR |
2003 |
- Khermkens Pedro Kharol'D Khan
- Lukas Khans
- Dols Pol' Peter Mari Antonius
- Revinkel Jokhannes Bernardus Marija
- Folmer Brigit Jokhanna Bernita
|
RU2309155C2 |
DERIVATIVES OF METHYLPIPERAZINE-AZEPINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1991 |
- Zhan-Fransua Fernand L'Ezhua[Be]
- Zhak Ehli Delarzh[Be]
|
RU2111966C1 |