TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE Russian patent published in 2014 - IPC C07D495/16 A61K31/519 A61P35/00 

Abstract RU 2520966 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide and its salts, such as hydrobromide, hydrochloride, methane sulfonate, ethane-1,2-disulfonate. The invention also relates to a medication and a pharmaceutical composition based on the said compound and its salts for inhibition of ATP-ase activity of HSP90.

EFFECT: novel compound and its salts, which can be applied in medicine for cancer treatment, are obtained.

23 cl, 10 ex

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Authors

Okhki Khitosi

Okajama Tooru

Ikeda Masakhiro

Ota Masakhiro

Sibata Josikhiro

Nakanisi Tosijuki

Ueda Jasusi

Suzuki Nobujuki

Matuura Sindzi

Dates

2014-06-27Published

2010-02-24Filed