FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a compound of formula 14 or its stereoisomer or tautomer, where in formula 14 Ea represents either hydrogen, hydroxy or a C1-C4alkoxy group; Eb represents either hydrogen, halogen, a C1-C4alkyl group or a C1-C4fluoroalkyl group; Ec and Ed each independently represents either hydrogen or hydroxy group; X' represents either hydrogen or hydroxy group; k is equal to an integer from 0 to 4; each Q independently represents either hydroxy, halogen, a C1-C4alkyl group, a hydroxy-C1-C4alkyl group, or a C1-C4alkoxy group; and Z' is a monovalent functional group represented by formula 15, where in formula 15 n is an integer from 1 to 5; each A independently represents a functional group selected from hydroxy, a C1-C4alkyl group, and a hydroxy-C1-C4alkyl group, and when n is two or more, then the two A can be spiro-linked to form 4.7-diazaspiro[2.5]octane; and L represents either hydrogen, a C1-C4alkyl group, a hydroxy group or a hydroxy-C1-C4alkyl group. The invention also relates to a method of inhibiting FLT3 kinase activity and a method of treating FLT3-mediated disease based on compounds of formula 14.
EFFECT: obtaining of new compounds that can be used in medicine for the treatment of cancer.
19 cl, 7 tbl, 32 ex
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